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Nineteen seventy-two was a stellar year for antibodies. The Nobel Prize in Medicine was shared by Porter and Edelman, whose studies, beginning in 1959, unraveled the chemical characteristics of these molecules. Their work eventually permitted precise amino acid mapping of the various polypeptide chains and localization of the antigenic determinants of immunoglobulin proteins, thereby launching a decade of remarkable progress in genetic control mechanisms of antibody structure and function. Indeed, keeping abreast of the developments in immunogenetics hardly seemed possible for the nonspecialist. This monograph, therefore, could not have appeared at a more opportune time. Written by members of an
Basic Immunogenetics.. Ann Intern Med. ;78:626–627. doi: 10.7326/0003-4819-78-4-626_3
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Published: Ann Intern Med. 1973;78(4):626-627.
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