MARSHALL B. BLOCK, M.D.; J. EDWARD BERK, M.D.; LOUIS S. FRIDHANDLER, Ph.D.; DONALD F. STEINER, M.D.; ARTHUR H. RUBENSTEIN, M.D.
A causal relation between infection with mumps virus and pancreatic endocrine and exocrine dysfunction is suggested by the occurrence of severe diabetic ketoacidosis and serum pancreatic amylase elevation in a patient with a significantly elevated mumps antigen titer. Sequential studies of beta cell secretion in the presence of exogenous insulin and insulin antibodies was accomplished by monitoring levels of C-peptide immunoreactivity. Secretion of proinsulin, C-peptide, and, presumably, insulin resumed after the acute episode and was associated with complete recovery of carbohydrate tolerance and cessation of insulin therapy. Serum amylase levels were persistently elevated, and a macroamylase was shown in the serum. However, the amylase released from the macroamylase complex by acidification presented different patterns at various stages of the patient's illness. Pancreatic-type amylase predominated during the acute phase, whereas the distribution of pancreatic-type and salivary-type amylase was essentially normal in samples taken several months later.
BLOCK MB, BERK JE, FRIDHANDLER LS, STEINER DF, RUBENSTEIN AH. Diabetic Ketoacidosis Associated with Mumps Virus Infection: Occurrence in a Patient with Macroamylasemia. Ann Intern Med. ;78:663–667. doi: 10.7326/0003-4819-78-5-663
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Published: Ann Intern Med. 1973;78(5):663-667.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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