MARSHALL B. BLOCK, M.D.; J. EDWARD BERK, M.D.; LOUIS S. FRIDHANDLER, Ph.D.; DONALD F. STEINER, M.D.; ARTHUR H. RUBENSTEIN, M.D.
A causal relation between infection with mumps virus and pancreatic endocrine and exocrine dysfunction is suggested by the occurrence of severe diabetic ketoacidosis and serum pancreatic amylase elevation in a patient with a significantly elevated mumps antigen titer. Sequential studies of beta cell secretion in the presence of exogenous insulin and insulin antibodies was accomplished by monitoring levels of C-peptide immunoreactivity. Secretion of proinsulin, C-peptide, and, presumably, insulin resumed after the acute episode and was associated with complete recovery of carbohydrate tolerance and cessation of insulin therapy. Serum amylase levels were persistently elevated, and a macroamylase was shown in the serum. However, the amylase released from the macroamylase complex by acidification presented different patterns at various stages of the patient's illness. Pancreatic-type amylase predominated during the acute phase, whereas the distribution of pancreatic-type and salivary-type amylase was essentially normal in samples taken several months later.
MARSHALL B. BLOCK, J. EDWARD BERK, LOUIS S. FRIDHANDLER, DONALD F. STEINER, ARTHUR H. RUBENSTEIN. Diabetic Ketoacidosis Associated with Mumps Virus Infection: Occurrence in a Patient with Macroamylasemia. Ann Intern Med. 1973;78:663–667. doi: 10.7326/0003-4819-78-5-663
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Published: Ann Intern Med. 1973;78(5):663-667.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Infectious Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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