JEAN KLASTERSKY, M.D.; BAUDOUIN VANDERKELEN, M.D.; DIDIER DANEAU; MONIGUE MATHIEU, M.D.
To the editor: Brunner and Frick (1) drew attention to the development of hypokalemia and metabolic alkalosis with high-dose sodium benzylpenicillin therapy; and electrolyte disturbances have been recorded occasionally in patients receiving carbenicillin (2).
During the last 2 years 90 patients were treated with carbenicillin (30 g daily) in our hospital; 25 received carbenicillin alone; 29 were treated with carbenicillin and gentamicin and 36 with carbenicillin and cephalothin. In 16 (18%) patients abnormally low levels of serum potassium were observed during therapy with carbenicillin. In 8 of these 16 patients hypokalemia was reported only once during antibiotic therapy; moreover, in
KLASTERSKY J, VANDERKELEN B, DANEAU D, MATHIEU M. Carbenicillin and Hypokalemia. Ann Intern Med. ;78:774–775. doi: 10.7326/0003-4819-78-5-774
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Published: Ann Intern Med. 1973;78(5):774-775.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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