LUIS FELIPE FAJARDO, M.D.
To the editor: Intravenous amphotericin B has produced clinical improvement or cure in 72% of patients with cryptococcal meningitis, a condition that was almost uniformly fatal before the advent of this drug (1). Little is known, however, about the response of cryptococcosis to topical amphotericin B, mainly because localized, accessible lesions are rare. The condition and treatment of the patient described below permitted a sequential study of the effect of topical amphotericin B on a cryptococcal infection.
A 45-year-old white man had Hodgkin's disease in a cervical lymph node. He was treated sucessfully with radiotherapy and chemotherapy. Seven years later
FAJARDO LF. Failure of Topical Amphotericin B in Cryptococcosis. Ann Intern Med. ;78:777–778. doi: 10.7326/0003-4819-78-5-777
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Published: Ann Intern Med. 1973;78(5):777-778.
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