Bert W. O'Malley, M.D.
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In viewing the sequence of events required in steroid hormone action, we must consider the large body of evidence that shows that steroid hormones combine with cytoplasmic receptor proteins almost immediately on entering the target cell. This is potentially a specific rate-limiting event in hormone action, since only target tissues contain appreciable quantities of receptor. Furthermore, the receptor itself will form a high-affinity complex only with steroid molecules that are biologically "active" in that tissue.
The steroid hormone-receptor complex is next transferred to the nuclear compartment, where it forms a second complex with certain chromatin "acceptor sites," comprising DNA and
O'Malley BW. Molecular Mechanisms of Steroid Hormone Action.. Ann Intern Med. ;78:812–813. doi: 10.7326/0003-4819-78-5-812_4
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Published: Ann Intern Med. 1973;78(5):812-813.
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