Martin Rodbell, Ph.D.
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A variety of peptide hormones derived from pituitary, hypothalamic, pancreatic, and intestinal endocrine cells initiate their actions at the surface or plasma membrane of target cells. Receptors, localized at the outer surface of these membranes, form specific and reversible complexes with the hormones. These complexes control a variety of membrane processes involved in electrical excitation and transport of amino acids, sugars, and ions. They also regulate the activities of certain enzymes imbedded in the matrix of the membrane. For example, adenylate cyclase, an enzyme that catalyzes the formation of cyclic AMP, is coupled to receptors for such varied hormones as
Rodbell M. Peptide Hormone Action and Membrane Receptors.. Ann Intern Med. 1973;78:813. doi: 10.7326/0003-4819-78-5-813_3
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Published: Ann Intern Med. 1973;78(5):813.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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