Bernard M. Patten, M.D.; John Belizikian, M.D.; Lawrence Mallette, M.D.; Alan Prince, M.D.; Gerald Aurbach, M.D.; W. King Engel, M.D.
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We report the first detailed study of the neurological, electromyographic, and muscle biopsy findings in patients with hyperparathyroidism.
Over 80% of our 16 patients presented with a distinct syndrome consisting of easy fatigability; weakness and atrophy of proximal muscles, particularly of the leg; tongue tremors; and normal or hyperactive reflexes. The presence or severity of weakness bore no relationship to the alteration of any serum ion measured, including calcium. The electromyograms showed short-duration, low-amplitude complex and, sometimes, polyphasic potentials mingled with high-amplitude, long-duration motor units. Motor and sensory nerve conduction times were normal. Muscle biopsies showed neurogenic atrophy of both
Patten BM, Belizikian J, Mallette L, Prince A, Aurbach G, Engel WK. Hyperparathyroid Neuromuscular Disease.. Ann Intern Med. ;78:815–816. doi: 10.7326/0003-4819-78-5-815_4
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Published: Ann Intern Med. 1973;78(5):815-816.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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