D. T. Lowenthal, M.D.; M. Kneiser, M.D.; William A. Briggs, M.D.; E. Jenis, M.D.
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Three patients with chronic hepatitis with either HAA or anti-HAA antibody and glomerulonephritis were studied to determine the relationship between these two disease processes. All had elevated levels of serum glutamic-pyruvic transaminase, serum glutamic-oxalactic transaminase, and alkaline phosphatase and various degrees of azotemia, creatinemia, and proteinuria. Onset of liver disease preceded the renal disease in two and in a third patient was associated with the development of a distinct glomerular disease, in addition to underlying congenital obstructive uropathy. Renal biopsies showed three distinct histologic types of glomerulonephritis: membranous, membranoproliferative, and focal. Further, electron microscopy showed clusters of viral-like particles in
Lowenthal DT, Kneiser M, Briggs WA, Jenis E. Immune-Complex Nephritis (ICN) with Hepatitis-Associated Antigen (HAA) in Chronic Hepatitis.. Ann Intern Med. ;78:817. doi: 10.7326/0003-4819-78-5-817_1
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Published: Ann Intern Med. 1973;78(5):817.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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