Daniel Hollander, M.D.; John Harlan, M.D.
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The ability of antacids to relieve discomfort and to promote healing of peptic ulcerations was compared with that of placebos in a randomized double-blind study. Seventy-three patients with radiologically or endoscopically proved active peptic ulcerations were randomly assigned to placebo-treated or antacid-treated groups and were followed and evaluated in a double-blind fashion. They were studied as outpatients and ate a regular diet, avoiding only caffeine, alcohol, and salicylates. Pain relief was assessed after 3 days and healing after 30 days of therapy.
In patients with duodenal ulcerations, 25 of 29 treated with antacids had pain relief, as compared with 17
Hollander D, Harlan J. Controlled Double-Blind Evaluation of Antacids and Placebos in Peptic Ulcer Therapy.. Ann Intern Med. 1973;78:818. doi: 10.7326/0003-4819-78-5-818_1
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Published: Ann Intern Med. 1973;78(5):818.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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