W. E. Connor, M.D., F.A.C.P.; S. N. Jagannathan, Ph.D.
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The occurrence of widespread hyperbetalipoproteinemia in the American population has heretofore been explained on a genetic basis. The hypothesis tested in this study was that an environmental factor, dietary cholesterol, might be an important contributing cause of beta lipoprotein elevation and, indirectly, atherosclerosis.
Eight normal persons, 4 with type II, and 3 with type IV hyperlipoproteinemia were given a cholesterol-free diet and then a high-cholesterol (1000 mg/day) diet, each for 3 weeks. Cholesterol and triglyceride were measured in plasma and in lipoprotein fractions. The values for total cholesterol and lipoprotein cholesterol after the high-cholesterol diet are shown in table below.
Connor WE, Jagannathan SN. The Production of Hyperbetalipoproteinemia and Hypercholesterolemia by Dietary Cholesterol in Normal, Type II, and Type IV Subjects.. Ann Intern Med. ;78:820–821. doi: 10.7326/0003-4819-78-5-820_3
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Published: Ann Intern Med. 1973;78(5):820-821.
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