Dhirendra S. Bana, M.D.; Perry S. MacNeal, M.D., F.A.C.P.; Philip M. LeCompte, M.D.; Yogendra Shah, M.D.; John R. Graham, M.D.
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Methysergide is probably causally related to the development of cardiac lesions in some patients taking this drug for headaches. We report our observations of the development and progress of cardiac murmurs in 36 of our own patients and 12 patients of other physicians, all taking methysergide. Murmurs were predominantly of aortic and mitral valve origin. Twelve patients had complete and 15 patients partial regression of the murmurs, 6 to 70 months after stopping use of the drug. Nine patients had retroperitoneal fibrosis, and two patients had pleuropulmonary fibrosis in addition to endocardial lesions. In four patients pathological material was available
Bana DS, MacNeal PS, LeCompte PM, Shah Y, Graham JR. Endocardial Fibrosis Associated with Methysergide Therapy.. Ann Intern Med. ;78:821–822. doi: 10.7326/0003-4819-78-5-821_4
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Published: Ann Intern Med. 1973;78(5):821-822.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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