Robert M. Nalbandian, M.D.; Bruce M. Nichols, B.S.; Noyes L. Avery Jr, M.D., F.A.C.P.; COL Frank R. Camp Jr
This content is PDF only. Please click on the PDF icon to access.
Urea in sugar solutions has been experimentally and clinically effective in the sickle-cell disease because of its demonstrated reversal and blocking actions on sickled erythrocytes. This beneficial effect has been attributed to the formation of cyanate in vivo and subsequent carbamylation of beta S globin chains. By controlled studies in oxygen-free atmospheres we have found that SS cells, protected from sickling by urea-sugar solutions (blood urea nitrogen level of 140 mg/100 ml), were again sickled after the addition of urease, which had no such effect on carbamylated cells.
Urea blocks and reverses sickling; urea-protected cells are
sickled by urease treatment;
Robert M. Nalbandian, Bruce M. Nichols, Noyes L. Avery, COL Frank R. Camp. Urea, Urease, Cyanate and the Sickling of Hemoglobin S.. Ann Intern Med. 1973;78:823–824. doi: 10.7326/0003-4819-78-5-823_4
Download citation file:
Published: Ann Intern Med. 1973;78(5):823-824.
Copyright © 2017 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use