B. A. Chabner, M.D., F.A.C.P.; H. R. Gralnick, M.D.; C. E. Myers, M.D.; V. T. DeVita, M.D., F.A.C.P.
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Bone marrow findings of 184 consecutive patients with Hodgkin's disease admitted to the National Cancer Institute since 1965 were reviewed to delineate pathologic changes. Marrow biopsies were evaluated in 128 patients and aspirates alone were examined in 56. The most frequent abnormalities were eosinophilia in 64% and erythroid hyperplasia in 47%. Marked granulocytic hyperplasia, resembling chronic granulocytic leukemia, was found in 7% and nonmalignant histiocytosis in 5%. Three types of direct tumor involvement were detected: total replacement of the biopsy specimen with diffuse myelofibrosis (DM) in nine patients—five had Reed-Sternberg cells (RSCs) and three had malignant histiocytosis; focal fibrosis with
B. A. Chabner, H. R. Gralnick, C. E. Myers, V. T. DeVita. Bone Marrow Involvement in Hodgkin's Disease (HD): Pathology and Clinical Implications.. Ann Intern Med. 1973;78:824. doi: 10.7326/0003-4819-78-5-824_2
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Published: Ann Intern Med. 1973;78(5):824.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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