Robert M. Blankenship, M.D.
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Advances in the management of renal failure necessitate a new look at the uremic patient. Infection is the leading cause of death in acute renal failure and the second most common cause of death in chronic uremia. The uremic patient must be regarded as an altered host more susceptible to infection. Some contributing factors are alterations of the skin and mucous membrane barriers, as well as lymphocyte and leukocyte dysfunction. Lymphocytes produce less interferon and also, when stimulated by phytohemagglutinin, show decreased metabolic activity in uremic serums. Leukocyte Chemotaxis is decreased. Other factors await more scientific investigation. Another important source
Blankenship RM. Hemodialysis and Infection.. Ann Intern Med. 1973;78:825. doi: 10.7326/0003-4819-78-5-825_3
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Published: Ann Intern Med. 1973;78(5):825.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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