W. H. Greene, M.D.; S. C. Schimpff, M.D.; V. M. Young, M.D.; P. H. Wiernik, M.D.
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The use of empiric, broad-spectrum antibiotic therapy in the treatment of presumed Gram-negative sepsis is nowhere more necessary than in the granulocytopenic patient, for without such therapy early (48 to 72 hours) death rates may exceed 50%. Since February 1971 the combination of carbenicillin, gentamicin, and cephalothin has been empirically applied to granulocytopenic (less than 1500/mm3), febrile (more than 38.3 °C [101 °F]) cancer patients at the first clinical suspicion of sepsis. In the ensuing 18 months 89 patients were treated for 177 such episodes, of which 103 were evaluable. (Nonevaluability was equated with either nonbacterial infection or no demonstrable
Greene WH, Schimpff SC, Young VM, Wiernik PH. Empiric Carbenicillin, Gentamicin and Cephalothin Therapy for Presumed Infection in Patients with Granulocytopenia and Cancer.. Ann Intern Med. ;78:825–826. doi: 10.7326/0003-4819-78-5-825_4
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Published: Ann Intern Med. 1973;78(5):825-826.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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