D. Churchill, M.D.; M. H. Gault, M.D., F.A.C.P.; J. Knaack, M.D.; C. Cole, M.D., F.A.C.P.; R. C. Muehrcke, M.D., F.A.C.P.
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Persistent renal dysfunction followed methoxyflurane anaesthesia in 2 patients. Each was elderly and had received 0.2% methoxyflurane for slightly longer than 4 hours. One developed polyuria, hypernatremia, and azotemia, postoperatively. Serum creatinine rose from 0.9 mg/100 ml, preoperatively, to a peak value of 2.9 mg/100 ml on the 8th postoperative day. Ffteen months after surgery the 24-hr creatinine clearance averaged 36 ml/ min, and maximum osmolality was 424 mosmol/kg of water after dehydration and vasopressin, The second patient had a slow rise in serum creatinine from 1.1 mg/100 ml before surgery to a peak value of 7.5 mg/100 ml on
Churchill D, Gault MH, Knaack J, Cole C, Muehrcke RC. Persistent Renal Failure Following Methoxyflurane Anaesthesia.. Ann Intern Med. ;78:827. doi: 10.7326/0003-4819-78-5-827_1
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Published: Ann Intern Med. 1973;78(5):827.
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