Hans R. Brunner, M.D.; Jean E. Sealey, B.Sc.; John H. Laragh, M.D., F.A.C.P.
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Classification of 219 patients with essential hypertension according to their renin levels has exposed three subgroups with different physiologic and epidemiological characteristics.
Twenty-seven percent of the patients had subnormal renin levels, and they have been shown previously to be relatively protected from heart attacks and strokes. These patients with low renin levels had a blunted aldosterone response to sodium deprivation, which was associated with significant potassium retention (P < 0.05) and a rise in plasma bicarbonate (P < 0.05). At all three levels of sodium intake low renin patients had the lowest blood urea nitrogen levels and therefore appeared to
Brunner HR, Sealey JE, Laragh JH. Characteristics of Renin Subgroups of Patients with Essential Hypertension.. Ann Intern Med. ;78:828. doi: 10.7326/0003-4819-78-5-828_2
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Published: Ann Intern Med. 1973;78(5):828.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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