Thomas Hoeppner, Ph.D.; Frank Morrell, M.D.; Jo Ann Hoeppner
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This study presents a preliminary examination of the relation between skin scarring and posttraumatic epilepsy.
Penfield has pointed out that in the meningocerebral cicatrix, which so commonly results from cerebral trauma, fibroblasts of mesodermal origin invade the brain tissue. Unlike scars of purely glial origin, those derived from mesodermal tissue contract and thus distort neuronal architecture, placing continuous tension on surrounding neural elements. Such mechanical deformation has been shown to produce partial dendritic depolarization, thereby sharply increasing excitability and producing sustained, high-frequency firing. It seems reasonable to suppose that a tendency to form exaggerated hypertrophic scars would be highly correlated
Hoeppner T, Morrell F, Hoeppner JA. Skin Scarring, Epilepsy, and Genetics.. Ann Intern Med. ;78:829–830. doi: 10.7326/0003-4819-78-5-829_3
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Published: Ann Intern Med. 1973;78(5):829-830.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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