Robert S. Benjamin, M.D.; Peter H. Wiernik, M.D.; Nicholas R. Bachur, M.D.
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This study was designed to evaluate the efficacy and toxicity of adriamycin in patients with metastatic sarcomas. Thus far 27 patients have been treated; 21 are presently evaluable. The dosage schedule was based on our pharmacologic observations of a long plasma half-life in patients with normal liver function and markedly elevated plasma levels, delayed drug elimination, and severe toxicity in patients with liver disease. One dose, 60 mg/m2 body surface area, was administered intravenously to patients with normal liver function. The dose was reduced by 50% to 75% for patients with liver disease, to achieve plasma levels comparable to those
Benjamin RS, Wiernik PH, Bachur NR. Adriamycin: A New Effective Therapy for Metastatic Sarcoma.. Ann Intern Med. ;78:831. doi: 10.7326/0003-4819-78-5-831_1
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Published: Ann Intern Med. 1973;78(5):831.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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