Saul VV. Rosen, M.D., F.A.C.P.; Bruce D. Weintraub, M.D.
This content is PDF only. Please click on the PDF icon to access.
Recent investigations in several laboratories have shown that the glycoprotein trophic hormones TSH, LH, hCG, and FSH, are composed of two biologically inactive subunits: a common, nearly identical alpha subunit and a beta subunit that confers specificity on the complete biologically active molecule. In the course of screening serums of cancer patients for ectopic placental protein production, we found a case with isolated production of the beta subunit of hCG (a 75-year-old man with mixed epidermoid-adenocarcinoma of the pancreas; serum hCG-β, 300 ng/ml) and another with isolated production of the alpha subunit (a 27-year-old woman with typical gastric carcinoid; serum
Rosen SV, Weintraub BD. Alpha and Beta HCG Subunit Disease: Recognition of New Ectopic Polypeptide Syndromes.. Ann Intern Med. ;78:831. doi: 10.7326/0003-4819-78-5-831_3
Download citation file:
Published: Ann Intern Med. 1973;78(5):831.
Copyright © 2019 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use