Saul VV. Rosen, M.D., F.A.C.P.; Bruce D. Weintraub, M.D.
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Recent investigations in several laboratories have shown that the glycoprotein trophic hormones TSH, LH, hCG, and FSH, are composed of two biologically inactive subunits: a common, nearly identical alpha subunit and a beta subunit that confers specificity on the complete biologically active molecule. In the course of screening serums of cancer patients for ectopic placental protein production, we found a case with isolated production of the beta subunit of hCG (a 75-year-old man with mixed epidermoid-adenocarcinoma of the pancreas; serum hCG-β, 300 ng/ml) and another with isolated production of the alpha subunit (a 27-year-old woman with typical gastric carcinoid; serum
Rosen SV, Weintraub BD. Alpha and Beta HCG Subunit Disease: Recognition of New Ectopic Polypeptide Syndromes.. Ann Intern Med. ;78:831. doi: 10.7326/0003-4819-78-5-831_3
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Published: Ann Intern Med. 1973;78(5):831.
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