E. Finder; G. Simons, R.N.; G. Huber, M.D.
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Therapeutic use of oxygen at toxic concentrations is often essential in managing acute and chronic respiratory failure. The following experiments on administration of 100% oxygen  define a progressive, dose-dependent toxicity for pulmonary structure and function after continuous exposure to oxygen,  demonstrate complete prevention of these toxic manifestations if an equivalent toxic dose is given by intermittent rather than continuous exposure, and  introduce a concept of "oxygen tolerance" in which toxic manifestations of continuous exposure are markedly reduced in animals first adapted either on an intermittent basis to a high oxygen environment (Po2, 700 mm Hg) or continuously
E. Finder, G. Simons, G. Huber. Adaptive Tolerance to Pulmonary Oxygen Toxicity After Hypoxia or Intermittent Hyperoxia.. Ann Intern Med. 1973;78:832. doi: 10.7326/0003-4819-78-5-832_2
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Published: Ann Intern Med. 1973;78(5):832.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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