HARRY R. LOCKE, M.D.; W. E. HATHAWAY, M.D.; FREDERIC FEILER, M.D.; DONALD L. DAWSON, M.D.
To the editor: Since 1967 several cases of a mild to moderately severe bleeding disorder associated with a platelet functional defect have been described (1-5). This disorder has been called "failure to release ADP [adenosine 5′-diphosphate]" and is characterized by normal coagulation studies, normal platelet counts, variable prolongation of the bleeding time, poor platelet retention in glass-bead filters (platelet adhesivity), and decreased aggregation of platelets by collagen and epinephrine. Platelet aggregation by exogenous adenosine 5′-diphosphate is usually normal.
Our report describes an additional case and documents correction of the defect by platelet transfusions during a surgical procedure.
The patient, a
LOCKE HR, HATHAWAY WE, FEILER F, DAWSON DL. Preoperative Correction of a Platelet Functional Disorder. Ann Intern Med. ;78:972–973. doi: 10.7326/0003-4819-78-6-972
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Published: Ann Intern Med. 1973;78(6):972-973.
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