DON C. MCLEOD, M.S. PHARM.
To the editor: There is a potentially serious error in the package insert for the new antifungal agent, flucytosine. The serum half-life is said to be from 4 to 8 hours, and a total, daily dose of 50 to 150 mg/kg body weight is recommended. The insert recommends using a daily dose of 50 mg/kg body weight in renal impairment. This recommendation does not consider the great range of "renal impairment" found clinically. It is known that 90% of the oral flucytosine dose is recovered unchanged in the urine. The quoted serum half-life of 4 to 8 hours was apparently
MCLEOD DC. Error in Flucytosine Dosage?. Ann Intern Med. 1973;78:978–979. doi: 10.7326/0003-4819-78-6-978
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Published: Ann Intern Med. 1973;78(6):978-979.
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