C. G. GEGICK, M.D.; T. S. DANOWSKI, M.D., F.A.C.P.; R. C. KHURANA, M.D., F.A.C.P.; C. VIDALON, M.D.; S. NOLAN, M.D.; T. STEPHAN, M.D.; S. CHAE, M.D.; L. WINGARD
Increased serum alkaline phosphatase levels were found in about one half of a group of 65 persons with hyperostosis frontalis interna. Comparisons of various clinical, endocrine, and metabolic indexes in a nonpatient population with and without hyperostosis frontalis interna showed that those with it were older, heavier, and had thicker skin folds, higher serum triglyceride levels, and a slightly shorter duration in one of four indexes of ankle reflex time. All other variables measured, including serum electrolytes and other solutes, glucose tolerance, thyroidal indexes, and plasma and urinary steroids, were the same in those with and those without hyperostosis frontalis interna. A review of published reports and of the findings in our patients does not provide clues as to the origin or the significance of such hyperphosphatasemia in patients with this curious bone lesion.
GEGICK CG, DANOWSKI TS, KHURANA RC, VIDALON C, NOLAN S, STEPHAN T, et al. Hyperostosis Frontalis Interna and Hyperphosphatasemia. Ann Intern Med. ;79:71–75. doi: 10.7326/0003-4819-79-1-71
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Published: Ann Intern Med. 1973;79(1):71-75.
Cardiology, Coronary Risk Factors, Dyslipidemia, Hospital Medicine, Neurology.
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