SERGIO JACOBELLI, M.D.; DANIEL J. McCARTY, M.D., F.A.C.P.; DONALD C. SILCOX, M.D.; JAY C. MALL, M.D.
Three men and one woman with late, latent syphilis and neurotrophic knee joints are reported here. One had calcium pyrophosphate dihydrate crystal deposition in several joints, without abnormal neurological changes; the other three showed some of the neurological lesions of tabes dorsalis and this joint deposition. We postulate a pathogenetic synergism of the two conditions. Because neuroarthropathy should be excluded before proceeding with endoprosthetic joint replacement, it is important to establish the cause of severe peripheral joint degeneration with precision, by careful neurologic, radiologic, and laboratory examination.
JACOBELLI S, McCARTY DJ, SILCOX DC, MALL JC. Calcium Pyrophosphate Dihydrate Crystal Deposition in Neuropathic Joints: Four Cases of Polyarticular Involvement. Ann Intern Med. ;79:340–347. doi: 10.7326/0003-4819-79-3-340
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Published: Ann Intern Med. 1973;79(3):340-347.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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