M. R. A. KHAIRI, M.D.; H. N. WELLMAN, M.D., F.A.C.P.; J. A. ROBB, M.D.; C. C. JOHNSTON JR., M.D., F.A.C.P.
The results of clinical, biochemical, radiological, and fluorine-18 bone scan observations on 22 symptomatic patients with Paget's disease are presented. "Sclerotic" lesions seen on radiographs were always asymptomatic. The involvement of ioints by Paget's disease was a major source of pain. A comparison of radiographic and bone scan findings showed that lesions seen by X ray and not by bone scan were always asymptomatic. In contrast, lesions seen by bone scan and not by X ray were symptomatic in most patients. We conclude that Na18F bone scan detects clinically active lesions more often and is an important adjunct to the assessment of skeletal involvement in patients with Paget's disease. These observations may have the bias inherent in selection of patients with "positive symptoms." The levels of serum alkaline phosphatase and urinary hydroxyproline showed highly significant correlation with percentage of skeletal involvement.
KHAIRI MRA, WELLMAN HN, ROBB JA, JOHNSTON CC. Paget's Disease of Bone (Osteitis Deformans): Symptomatic Lesions and Bone Scan. Ann Intern Med. ;79:348–351. doi: 10.7326/0003-4819-79-3-348
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Published: Ann Intern Med. 1973;79(3):348-351.
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