G. A. DESROCHES; C. L. BRADSHAW; O. W. JONES, M.D.
Three generations in a kindred have been studied for identification of a chromosome structural rearrangement not previously described in man. Staining by G-banding methods identified the rearrangement as a truly reciprocal, balanced translocation involving chromosome pairs 1 and 2. This study shows the sensitivity of new staining methods in confirming a reciprocal exchange of genetic information and in identifying break-point regions on each chromosome.
DESROCHES GA, BRADSHAW CL, JONES OW. A Balanced Reciprocal Chromosomal Translocation in Three Generations: Identification by Giemsa Staining. Ann Intern Med. 1973;79:407–410. doi: 10.7326/0003-4819-79-3-407
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Published: Ann Intern Med. 1973;79(3):407-410.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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