HOWARD RUBINOFF, M.D.
To the editor: I would appreciate it if Dr. Frohlich could document his suggestion (Ann Intern Med 78: 717-723, 1973) that the "loop of Henle" diuretics may be more effective than the thiazides in the management of hypertension in patients with renal functional impairment. I am not aware of any studies substantiating this statement; to the contrary, Dr. Anderson and his colleagues (Q J Med 40:541-560, 1971) concluded that the thiazides were twice as effective as "frusemide" (furosemide) in the treatment of hypertension. The loop diuretics are more expensive and potentially more harmful than the thiazides.
HOWARD RUBINOFF. Diuretics in Hypertension. Ann Intern Med. 1973;79:455. doi: 10.7326/0003-4819-79-3-455_1
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Published: Ann Intern Med. 1973;79(3):455.
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