GERALD L. MANDELL, M.D., F.A.C.P.
Cephaloridine (Loridine®) is a cephalosporin antibiotic for parenteral use that has antibacterial activity similar to that of cephalothin (Keflin®). Cephaloridine is less painful on intramuscular injection than cephalothin. Doses greater than 4 g daily may be nephrotoxic to normal patients, and smaller doses may damage the kidneys of patients with underlying renal disease or those receiving other nephrotoxic drugs. Therefore renal function should be monitored before and during cephaloridine therapy. Cephaloridine will probably be replaced as "the intramuscular cephalosporin" by new cephalosporin antibiotics that are as well tolerated by the intramuscular route but do not have significant nephrotoxic hazard.
MANDELL GL. Drug Five Years Later: Cephaloridine. Ann Intern Med. ;79:561–565. doi: 10.7326/0003-4819-79-4-561
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Published: Ann Intern Med. 1973;79(4):561-565.
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