DAVID S. NEWCOMBE, M.D.
To the editor: The incidence of acute gouty arthritis as a complication of chronic nongouty renal disease is less than 1% (1, 2). Of a total of 11 unrelated patients with adult polycystic disease seen at our institution over the past 4 years, 4 have had documented acute gouty arthritis. This high incidence (36%) of gout occurring in polycystic kidney disease suggests that investigation of urate metabolism in this heritable disorder might help to resolve the following problems:  the effect of hyperuricemia on the functionally compromised kidney;  the effect of hypouricemic therapy on the progression of the renal
NEWCOMBE DS. Gouty Arthritis and Polycystic Kidney Disease. Ann Intern Med. 1973;79:605. doi: 10.7326/0003-4819-79-4-605
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Published: Ann Intern Med. 1973;79(4):605.
Gout, Nephrology, Rheumatology.
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