JAMES F. TOOLE, M.D.
A quarter of a century ago Seymour Kety and Carl F. Schmidt of the University of Pennsylvania devised a method of measuring cerebral blood flow in man (1, 2). Their system, based on the Fick principle, was safe enough for use both in normal volunteers and in patients. As a consequence, it broadened the study of man's brain from bedside and autopsy-table observations to the physiologist's laboratory.
Kety and Schmidt were joined by Dr. Louis Sokoloff (3) who contributed much with his studies of cerebral blood flow and metabolism. Their studies showed that the arterioles controlling brain blood flow are
TOOLE JF. Cerebral Blood Flow After 25 Years. Ann Intern Med. ;79:744–745. doi: 10.7326/0003-4819-79-5-744
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Published: Ann Intern Med. 1973;79(5):744-745.
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