W. LAWRENCE DREW, M.D., PH.D.; MYRON R. BLUME, M.D., PH.D.; RICHARD MINER, B.A.; IVAN SILVERBERG, M.D.; ERNEST H. ROSENBAUM, M.D., F.A.C.P.
To the editor: Varicella-zoster virus infections are potentially lethal in patients with defective cell-mediated immunity. Such susceptibility might be "repaired" by transfer factor. We have attempted to treat disseminated herpes zoster with transfer factor from a donor whose lymphocytes reacted in vitro to varicella-zoster antigen.
A man, 44 years old, with Hodgkin's disease, stage IVB, was hospitalized with disseminated herpes zoster. His generalized vesicular lesions showed little evidence of crusting and healing. Fluorescent antibody examination of a skin lesion was positive for varicella-zoster, and the virus was cultured from a skin lesion. The leukocyte count was 5700/mm3, with 75% polymorphonuclear
DREW WL, BLUME MR, MINER R, SILVERBERG I, ROSENBAUM EH. Herpes Zoster: Transfer Factor Therapy. Ann Intern Med. ;79:747–748. doi: 10.7326/0003-4819-79-5-747
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Published: Ann Intern Med. 1973;79(5):747-748.
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