DOV GORSHEIN, M.D.; EMMANUEL C. BESA, M.D.; FRANK H. GARDNER, M.D.
To the editor: The current concept of remission in acute leukemia is associated with the degree of "cell kill"—longer remissions with greater cell kill. A cure means total cell kill. Weintraub (1) recently proposed that agents effective in therapy for acute leukemia induce differentiation of primitive stem cells.
Treatment with androgens for refractory anemia in a man who had preleukemia resulted in a stable course with a normal hemogram. Cessation of therapy was associated with the development of acute leukemia. It is speculated that androgens trigger cells into a cycle that responds to differentiating factors (erythropoietin), thus keeping the patient
DOV GORSHEIN, EMMANUEL C. BESA, FRANK H. GARDNER. Acute Myelomonocytic Leukemia After Cessation of Androgen Therapy. Ann Intern Med. 1973;79:749–750. doi: 10.7326/0003-4819-79-5-749
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Published: Ann Intern Med. 1973;79(5):749-750.
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