IAN L. GARRIQUES, M.D.; RICHARD J. DUMA, M.D.
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To the editor: Menda and Gorbach (Ann Intern Med 78:25-32, 1973), in describing their experience with 23 cases of bacterial endocarditis, mention six patients treated with clindamycin, five of whom were infected with Staphylococcus aureus and one with Streptococcus viridans. One patient with S. aureus infection failed to respond and was treated subsequently with cephalothin. Elmore and his associates, in a follow-up letter (78:779-780, 1973), described a case of S. aureus endocarditis, that was successfully treated with clindamycin but complicated by "clindamycin hepatotoxicity."
Less the readers be inclined to accept clindamycin as a suitable alternate to the penicillins in treating
GARRIQUES IL, DUMA RJ. Bacterial Endocarditis: Failure with Clindamycin. Ann Intern Med. ;79:756–757. doi: 10.7326/0003-4819-79-5-756_3
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Published: Ann Intern Med. 1973;79(5):756-757.
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