THOMAS H. STEEL, M.D.; ARTHUR A. SERPICK, M.D.; JEROME B. BLOCK, M.D.
To the editor: We were interested in the article of DeFronzo and his associates, "Water Intoxication in Man After Cyclophosphamide Therapy" (Ann Intern Med 861-869, 1973), which indicates a high degree of clinical relevance for certain of our observations (1, 2) on the short-term effects of intravenous cyclophosphamide on the renal diluting mechanism in man.
Although differences in cyclophosphamide dosage, speed of drug administration, and experimental design between their studies and ours could explain some of the differences in results, our interpretations of the data differ importantly.
First, doses of cyclophosphamide considerably less than 50 mg/kg body weight seem to
THOMAS H. STEEL, ARTHUR A. SERPICK, JEROME B. BLOCK. Water Intoxication and Cyclophosphamide. Ann Intern Med. 1973;79:763–764. doi: 10.7326/0003-4819-79-5-763_2
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Published: Ann Intern Med. 1973;79(5):763-764.
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