MELVIN YUDIS, M.D.; SIGMUND GREENBERG, M.D.
To the editor: The article, "Rapid Correction of Hyponatremia in the Syndrome of Inappropriate Secretion of Antidiuretic Hormone", by Hantman and colleagues (Ann Intern Med 78:870-875, 1973), focuses on treating the life-threatening cerebral dysfunction of severe hyponatremia. His method uses furosemide-induced diuresis and simultaneous intravenous replacement of urinary cation losses.
We wish to report our recent experiences in the rapid reversal of severe hyponatremia in this syndrome (1). It combines the use of furosemide, which decreases sodium reabsorption in the proximal tubule and loop of Henle, and the potent mineralocorticoid desoxycorticosterone acetate (DOCA), which selectively increases sodium reabsorption (without much
YUDIS M, GREENBERG S. Correction of Hyponatremia. Ann Intern Med. ;79:764–765. doi: 10.7326/0003-4819-79-5-764
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Published: Ann Intern Med. 1973;79(5):764-765.
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