The synthesis of Australia or hepatitis B antigen (HB Ag) is now considered to be the characteristic hallmark of infection by hepatitis B virus (HBV) and is therefore one of the most important criteria in the diagnosis of type B hepatitis. Hepatitis-B antigenic reactivity is associated with the surface of the spherical and tubular particles (20 nm in diameter) found in the serum of patients and carriers. The outer coat of the relatively rare 42-nm "Dane" particles also exhibits this HB-Ag reactivity, but their inner component or "core" is antigenically distinct. At the moment, the most credible claimants to the
Subtypes of Hepatitis B Antigen: Clinical Relevance?. Ann Intern Med. ;79:894–896. doi: 10.7326/0003-4819-79-6-894
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Published: Ann Intern Med. 1973;79(6):894-896.
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