HANS-PETER LOHRMANN, M.D.; MALCOLM I. BULL, M.D.; JULIAN A. DECTER, M.D.; RONALD A. YANKEE, M.D.; ROBERT G. GRAW Jr., M.D.
Patients needing long-term platelet transfusion support become alloimmunized to transplantation (HL-A) antigens present in random-donor blood products, which results in refractoriness to platelets from unselected donors. Three thousand HL-A typed donors were used to evaluate the effectiveness of selecting unrelated platelet donors for alloimmunized patients by donor-recipient lymphocyte HL-A compatibility. Platelet transfusions from HL-A compatible donors resulted in increased platelet increments after transfusion. There was a positive correlation between the degree of donor-recipient HL-A compatibility and the transfusion response; the responses to platelets from A-matched donors (HL-A identical) and B-1-matched donors (HL-A compatible, one recipient antigen not present in the donor) were similar to platelet transfusions from HL-A identical siblings. ABO-incompatibility of HL-A compatible platelet donors did not affect the posttransfusion platelet increments. HL-A compatible platelet donors can be used effectively for transfusion support of alloimmunized patients.
LOHRMANN H, BULL MI, DECTER JA, YANKEE RA, GRAW RG. Platelet Transfusions From HL-A Compatible Unrelated Donors to Alloimmunized Patients. Ann Intern Med. ;80:9–14. doi: 10.7326/0003-4819-80-1-9
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Published: Ann Intern Med. 1974;80(1):9-14.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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