VICTOR GRANN, M.D., F.A.C.P.; ROBERT ERICHSON, M.D., F.A.C.P.; JOHN FLANNERY, B.S.; STUART FINCH, M.D., F.A.C.P.; BAYARD CLARKSON, M.D., F.A.C.P.
The records of ninety-three patients with acute granulocytic leukemia, who were more than 50 years old and were treated at a university hospital, a cancer center, and at seven community hospitals in Connecticut, were reviewed. Twenty-eight, or 44%, of patients treated with cytosine arabinoside and thioguanine attained a complete remission. This was increased to 51%, if patients treated for less than 30 days were excluded. Forty percent of patients in complete remission are alive at 25 months. The median survival time of patients attaining a complete remission was 19 months, as compared with 2 months for patients not attaining a remission. Age had no effect on remission rate, although patients 50 to 59 years of age appear to have a slightly longer survival time. No difference was noted in remission rate or survival of patients treated in the community hospital, cancer center, or university hospital. This study indicates that patients more than 50 years old have the opportunity for nearly the same response rate and survival as younger patients with acute granulocytic leukemia.
GRANN V, ERICHSON R, FLANNERY J, FINCH S, CLARKSON B. The Therapy of Acute Granulocytic Leukemia in Patients More Than Fifty Years Old. Ann Intern Med. ;80:15–20. doi: 10.7326/0003-4819-80-1-15
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Published: Ann Intern Med. 1974;80(1):15-20.
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