M. NATHAN LASSMAN, M.D.; MYRON GENEL, M.D.; JONATHAN K. WISE, M.D.; ROSA HENDLER, M.D.; PHILIP FELIG, M.D., F.A.C.P.
Glucose tolerance and pancreatic alpha and beta cell functions were evaluated in eight thalassemic patients, from 5 to 31 years old, receiving chronic transfusion therapy. Two patients had insulin-dependent diabetes, and two had a diabetic glucose tolerance test; one patient had a blood glucose response compatible with reactive hypoglycemia. All but two patients had a delayed or diminished insulin response, or both, to glucose infusion. In seven of eight patients the glucagon response to infusion of alanine was significantly reduced. Abnormalities of carbohydrate homeostasis are frequently seen in regularly transfused thalassemic patients. In such patients iron overload often results in diminished alpha and beta cell function.
LASSMAN MN, GENEL M, WISE JK, HENDLER R, FELIG P. Carbohydrate Homeostasis and Pancreatic Islet Cell Function in Thalassemia. Ann Intern Med. ;80:65–69. doi: 10.7326/0003-4819-80-1-65
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Published: Ann Intern Med. 1974;80(1):65-69.
Hematology/Oncology, Red Cell Disorders.
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