MANFRED D. MUENTER, M.D.
The paper by Frame and his associates in this issue about effects of hypervitaminosis A is the most recent of numerous reports on this problem. In 1857 Kane (1), American explorer of the Arctic, described the occurrence of symptoms of acute vitamin A intoxication after ingestion of polar bear liver. Chronic hypervitaminosis A is a well-recognized condition in children (2) and adults (3). The intake of vitamin A in the three patients reported by Frame and his associates was sufficient to cause the clinical picture of hypervitaminosis A; however, all three patients also had been taking vitamin D, admittedly in
MUENTER MD. Hypervitaminosis A. Ann Intern Med. ;80:105–106. doi: 10.7326/0003-4819-80-1-105
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Published: Ann Intern Med. 1974;80(1):105-106.
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