WILLIAM E. BARRY, M.D., F.A.C.P.
To the editor: In his editorial note, "Iron Kinetics in Man: New Studies with Mouse Hemoglobin," (Ann Intern Med 79:271-272, 1973), Fairbanks cites the work of Dresch and Najean (1), who used mouse hemoglobin as a marker of the catabolic limb of iron metabolism in the reticuloendothelial system in man. Their conclusions are based on the belief, previously shared by others (2), including us (3), that the hemoglobin-haptoglobin complex, in small amounts, is removed by the reticuloendothelial system. Notwithstanding their reference to histologic evidence supporting this in rats (4), other studies (5, 6) of rats have clearly shown that hemoglobin coupled with haptoglobin
WILLIAM E. BARRY. Iron Kinetics. Ann Intern Med. 1974;80:115. doi: 10.7326/0003-4819-80-1-115_1
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Published: Ann Intern Med. 1974;80(1):115.
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