MARIUS PESSAH, M.D.; WILLIAM FRANK, M.D.
To the editor: The recent NIH conference on hyperparathyroidism (Ann Intern Med 79:566-581, 1973) reviewed 57 cases of primary hyperparathyroidism, with weakness, fatigability, polyuria, and polydipsia being prominent symptoms. Of these patients, 24% had reduced serum bicarbonate concentrations and 9% had serum chloride levels greater than 110 meq/litre; 39% had serum chloride levels greater than 107 meq/ litre. Although it was briefly mentioned that this "was probably caused directly by the effect of parathyroid hormone on the kidney," we believe that the association between renal tubular acidosis, or the Fanconi syndrome, and parathyroid disease explains many of the clinical and
PESSAH M, FRANK W. Hyperparathyroidism and Renal Tubular Acidosis. Ann Intern Med. ;80:116–117. doi: 10.7326/0003-4819-80-1-116_2
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Published: Ann Intern Med. 1974;80(1):116-117.
Endocrine and Metabolism, Parathyroid Disorders.
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