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Strains of falciparum malaria that are resistant to the 4-aminoquinolones were first reported in 1960, but the full significance of this phenomenon was not appreciated by most American physicians until the 1965 build-up of U.S. military personnel in Southeast Asia. The field trials and research efforts generated by the experience with chloroquine-resistant falciparum malaria in that theater are an important part of the present report. Also brought to light is the problem of resistance to the dehydrofolate reductase inhibitors of which pyrimethamine is the prototype. Publication at the present time is particularly timely in light of the large-scale troop withdrawals
Chemotherapy of Malaria and Resistance to Antimalarials.. Ann Intern Med. ;80:129–130. doi: 10.7326/0003-4819-80-1-129_3
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Published: Ann Intern Med. 1974;80(1):129-130.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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