GERASIMOS G. KARVOUNTZIS, M.D.; ALLAN G. REDEKER, M.D.
Serums of 104 patients with acute hepatitis of variable severity were tested for alpha-fetoprotein by counterelectrophoresis. Among 51 patients with fulminant hepatitis and coma, alpha-fetoprotein was detected in 17 (85%) of 20 who survived and in only 12 (38.7%) of 31 fatal cases (P = 0.002, Fisher's exact test). Among 53 patients without coma, alpha-fetoprotein was detected in 16. Alpha-fetoprotein positivity was found to be related to the severity of the disease, and its appearance was followed by recovery in these patients. The high levels of alpha-fetoprotein observed in severe forms of hepatitis may represent active hepatocyte regeneration after extensive hepatic necrosis. Moreover, the presence of alpha-fetoprotein seems to be a favorable prognostic sign.
KARVOUNTZIS GG, REDEKER AG. Relation of Alpha-Fetoprotein in Acute Hepatitis to Severity and Prognosis. Ann Intern Med. ;80:156–160. doi: 10.7326/0003-4819-80-2-156
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Published: Ann Intern Med. 1974;80(2):156-160.
Gastroenterology/Hepatology, Liver Disease.
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