FRED J. PALMER, M.D.; JERALD C. NELSON, M.D., F.A.C.P.; HABEEB BACCHUS, M.D., Ph.D., F.A.C.P.
Serum chloride and phosphate concentrations were measured in 52 hypercalcemic patients. The chloride values were higher (mean, 107 meq/litre) and phosphate, lower (mean, 2.6 mg/100 ml) in the 25 hyperparathyroid patients, whereas the chloride concentrations were lower (mean, 98 meq/litre) and phosphate, higher (mean, 4.5 mg/100 ml) in the 27 patients with hypercalcemia from other causes. The chloride-to-phosphate ratio ranged from 31.8 to 80 in hyperparathyroidism, with 96% more than 33, and from 17.1 to 32.3 in those with hypercalcemia from other causes, with 92% less than 30. The chloride-to-phosphate ratio differentiated well between these two groups of hypercalcemic patients.
PALMER FJ, NELSON JC, BACCHUS H. The Chloride-Phosphate Ratio in Hypercalcemia. Ann Intern Med. ;80:200–204. doi: 10.7326/0003-4819-80-2-200
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Published: Ann Intern Med. 1974;80(2):200-204.
Endocrine and Metabolism, Fluid and Electrolyte Disorders, Nephrology.
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