CARROLL E. CROSS, M.D.
Two cell types predominate in mammalian alveolar epithelium:  Type I cells (membranous pneumonocytes), which have a small, nucleated cell body with attenuated peripheral cytoplasm containing a relative paucity of intracytoplasmic organelles, and which cover most of the alveolar surface; and  Type II cells (granular pneumonocytes), which are nearly cuboidal with abundant cytoplasmic organelles, including moderate amounts of endoplasmic reticulum, ribosomes, and lamellar inclusions, and which cover areas of the alveolar surface not lined by type I cells. The lamellar inclusions of the type II cells represent sites of synthesis of pulmonary surfactant, the phospholipid-rich substance primarily responsible for
CARROLL E. CROSS. The Granular Type II Pneumonocyte and Lung Antioxidant Defense. Ann Intern Med. 1974;80:409–411. doi: 10.7326/0003-4819-80-3-409
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Published: Ann Intern Med. 1974;80(3):409-411.
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