DIETER KLEINKNECHT, M.D.; PAUL JUNGERS, M.D.; JEAN-PAUL FILLASTRE, M.D.
To the editor: In his paper on cephaloridine (Ann Intern Med 79:561-565, 1973), Dr. Mandell reviewed the nephrotoxicity of this drug. He stated that "numerous reports also attest that treatment with doses of 4 g or less daily, in patients with normal renal function, does not result in detectable renal impairment."
We recently reported (1) 13 patients in whom acute anuric renal failure appeared after cephaloridine therapy prescribed for bacterial endocarditis or other infectious diseases; 6 of them had previously normal renal function but developed renal failure after receiving daily doses of 4 g or less (Table 1). As was
KLEINKNECHT D, JUNGERS P, FILLASTRE J. Nephrotoxicity of Cephaloridine. Ann Intern Med. ;80:421–422. doi: 10.7326/0003-4819-80-3-421
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Published: Ann Intern Med. 1974;80(3):421-422.
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