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Medical oncology as a therapeutic discipline began in the late 1940s with the introduction of the nitrogen mustards and antifolate agents. In the subsequent 25 years we have witnessed the bewildering development of a multitude of chemotherapeutic agents characterized, in general, by a low therapeutic index. The use of these agents, singly and in combination, has provided an unprecedented challenge to the pharmacologist and the chemotherapist. The controlled clinical trials of the cancer medicine researchers have become models for the collection of objective clinical data now being taken up in other branches of medicine. The editors and their contributors have
Cancer Medicine.. Ann Intern Med. ;80:431. doi: 10.7326/0003-4819-80-3-431_1
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Published: Ann Intern Med. 1974;80(3):431.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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