ROBERT MATALON, M.D., F.A.C.P.; LOIS KATZ, M.D.; GLORIA GALLO, M.D.; ELAINE WALDO, M.D.; CLAUDIA CABALUNA, M.D.; ROBERT P. EISINGER, M.D., F.A.C.P.
Ten adults with the nephrotic syndrome and sterile pyuria are described. On biopsy they had varying degrees of glomerular sclerosis without proliferation. Interstitial inflammation and fibrosis and tubular atrophy were often prominent. Glomerular basement membranes stained for IgG in a uniform, linear distribution and were devoid of discrete electron-dense deposits on electron microscopy. The course of disease was generally one of insidious onset, progressive azotemia, and unresponsiveness to therapy. This form of glomerular sclerosis with linear immune deposits has not previously been described and should be considered in the differential diagnosis of steroid-resistant nephrotic syndrome in adults.
MATALON R, KATZ L, GALLO G, WALDO E, CABALUNA C, EISINGER RP. Glomerular Sclerosis in Adults with Nephrotic Syndrome. Ann Intern Med. ;80:488–495. doi: 10.7326/0003-4819-80-4-488
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Published: Ann Intern Med. 1974;80(4):488-495.
Nephrology, Nephrotic Syndrome.
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